Doonesbury by Garry Trudeau for December 10, 1973
Joanie: Ellie? What's wrong, dear? Girl: It's mother... she's pregnant - and due any day! Joanie: But... that's wonderful! Girl: No, it's not. Five years ago it was wonderful. Now it's just redundant. Joanie: You mean... Girl: Four brothers. Four of the meanest, most miserable creatures ever conceived! Joanie: Oh dear... Girl: I've got to get her to call it off!