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Doonesbury by Garry Trudeau for January 14, 1978
Voice: I don't know what to do, Zonker! The lecture starts in an hour, and your uncle is in a total stupor! Zonker: What do you mean, a stupor, Ronnie? Voice: Well, he's just lying in his bed with a silly grin on his face! And the place is just littered with little plastic vials! Hmm... sounds like he's been out shopping... now, where do you suppose he got the money to buy... say, Ronnie, I don't suppose you paid him in advance? Voice: I had to, Zonk! His mother needed an operation right away!