Doonesbury by Garry Trudeau for August 16, 1977
Zonker: Duke, you sure you want to be taking those just before your speech? Duke: Best time! It's going to be a long evening! Zonker: What's in them, Duke? Duke: Something very special. An extract made from the pineal glands of male adolescent iguanas. ZOnker: Whatever happened to grass? Duke: Beats me! You can't even get arrested for it any more!